I joined the lab in 2011 as a postdoctoral research associate having completed my PhD in the University of Liverpool where I was investigating the dynamics of the transcription factor NF-kB. My research has been focused around using quantitative approaches to understand how cells interact and signal to each other to specify and control decisions about their fates and organization in development and homeostasis.
I am currently using our newly developed Gastruloid model system to study the patterning events that occur during early development such as the specification of the anteroposterior, dorsoventral and Left-Right axes. Using live-cell imaging and immunofluorescence of fixed samples, these patterning events can be measured and quantified, and compared to the processes in the mouse embryo.
Turner, D. A.*, Glodowski CR, Alonso-Crisostomo L, Baillie-Johnson P, Hayward PC, Collignon J, Gustavsen, C, Serup P, Schröter C, and Martinez Arias A*. Interactions between Nodal and Wnt signalling Drive Robust Symmetry-Breaking and Axial Organisation in Gastruloids (Embryonic Organoids). BioRxiv (2016) DOI: doi: 10.1101/051722. (*Joint corresponding author)
Turner, D. A.*, Baillie-Johnson, P. and Martinez Arias, A*. Organoids and the genetically encoded self-assembly of embryonic stem cells. Bioessays (2016) 38 (2); (*Joint corresponding author)
Baillie-Johnson, P., van den Brink, S. C., Balayo, T., Turner, D. A. and Martinez Arias, A. Generation of Aggregates of Mouse Embryonic Stem Cells that Show Symmetry Breaking, Polarization and Emergent Collective Behaviour in vitro. Journal of Visualized Experiments (2015); 105, e53252.
van den Brink, S. C., Baillie-Johnson, P., Balayo, T., Hadjantonakis, A.-K., Nowotschin, S., Turner, D. A. and Martinez Arias, A. Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells. Development (2014) 141, 4231–4242.
Turner, D. A., Hayward, P. C., Baillie-Johnson, P., Rué, P., Broome, R., Faunes, F. and Martinez Arias, A. Wnt/β-catenin and FGF signalling direct the specification and maintenance of a neuromesodermal axial progenitor in ensembles of mouse embryonic stem cells. Development (2014) 141, 4243–4253.
Turner, D. A.*, Rué, P., Mackenzie, J. P., Davies, E. and Martinez Arias, A.*. Brachyury cooperates with Wnt/β-Catenin signalling to elicit Primitive Streak like behaviour in differentiating mouse ES cells. BMC Biology (2014) 12, 63; (*Joint corresponding author)
Turner, D. A., Trott, J., Hayward, P., Rué, P. and Martinez Arias, A. An interplay between extracellular signalling and the dynamics of the exit from pluripotency drives cell fate decisions in mouse ES cells. Biology Open (2014) 3, 614–626.
Turner, D. A., Paszek, P., Woodcock, D. J., Nelson, D. E., Horton, C. A., Wang, Y., Spiller, D. G., Rand, D. A., White, M. R. H. and Harper, C. V.. Physiological levels of TNFalpha stimulation induce stochastic dynamics of NF-kappaB responses in single living cells. Journal of Cell Science (2010) 123, 2834–2843.
Jameson, D., Turner, D. A., Ankers, J., Kennedy, S., Ryan, S., Swainston, N., Griffiths, T., Spiller, D. G., Oliver, S. G., White, M. R. H., Kell, D. B., and Paton N. W. Information management for high content live cell imaging. BMC Bioinformatics (2009) 10, 226.