Stefano Vianello

Profilesdv20@cam.ac.uk

EDUCATION

 MPHIL BIOLOGICAL SCIENCE (GENETICS) | 2016-2017
GIRTON COLLEGE, UNIVERSITY OF CAMBRIDGE
“Wnt and Notch (Wntch) interplay as a molecular governor of transition state dynamics”, with Prof A. Martinez-Arias.

BA HONS NATURAL SCIENCES | 2013 – 2016
GIRTON COLLEGE, UNIVERSITY OF CAMBRIDGE
(First Class Honours): Human Genome, Genomics, SysBio; Developmental Genetics; Chromosomes & Cell cycle; Evolutionary Genetics; Plant & Microbial Genetics

EUROPEAN BACCALAUREATE | 2006-2013
EUROPEAN SCHOOL OF BRUSSELS II

governor

I officially joined the AMA group in October 2016 (MPhil), although I have been in and out of the lab in the past two years as an undergraduate student.

My current research project aims to elucidate the relationship between the two signal transduction pathways Wnt and Notch, and their functional interplay in governing key aspects of early embryonic development. Specifically, and following results obtained as an undergraduate, I am interested in a possible post-transcriptional role of the Notch intracellular domain as a β-catenin-independent inhibitor of Wnt signalling. I would also like to expand on this and characterise the role played by the “Wntch” (Wnt + Notch) machinery in integrating information and governing state-transition dynamics.

Outside the lab, I am also leading the Synthetic Biology Society’s (CUSBS) biological project on gene regulatory networks, feedback loops, and synthetic circuit design in cell-free transcription-translation systems. My main objective is to foster a philosophy of collaboration and mutual learning between students from different scientific backgrounds, and promote interdisciplinarity.


Embryos, stem cells, and gastruloids: a spatialist interpretation of developmental biology

The challenge faced by developmental biologists is not an easy one: the embryo is a system under continuous change, where single cells navigate space, time, states and fates accordingly to mechanisms that are still poorly understood. Yet, these mechanisms must … Continue reading

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