Last week the on-line version of Development published our manuscript â€œA membrane-associated Î²-catenin/Oct4 complex correlates with ground-state pluripotency in mouse embryonic stem cells.â€ Development. 2013 Mar;140(6):1171-83. doi: 10.1242/dev.085654.. Given its checkered history (see the forthcoming blog Â â€œWhat I learnt from a rejectionâ€ ) we were delighted. The work gets close to settle ongoing debates about the impact of ÃŸ-catenin, the transcriptional effector of Wnt signalling, on pluripotency in mouse ES cells. It concurs that while ÃŸ-catenin contributes to the self renewal of the pluripotent state, this effect is not mediated by its transcriptional activity. We show that ÃŸ-catenin/Tcf mediated transcription is very low in self renewing ES cells which, nonetheless, have most of their ÃŸ-catenin associated with the membrane. Looking at the relationship between ÃŸ-catenin and the components of the pluripotency network we uncover the existence of a membrane associated ÃŸ-catenin/Oct4 complex. The amount of this complex correlates with the degree of pluripotency which suggests that it does play a role in the biology of the ES cells. There are some surprises here and time (and of course more experiments) will tell whether the interactions and functional relationships that we describe are important (as we suspect) or just another anecdote of the ES cells world.