New publication on “symmetry breaking in ensembles of ES cells”
Progress on our attempts to understand the connection between genes, signals, cells and embryos have just been published in Development. In a first paper we describe a new experimental system in which we coax mouse Embryonic Stem cells to make structures with an anterior posterior axis and a germ layer organization that resembles that of an embryo (http://dev.biologists.org/content/141/22/4231.full). In a second paper we use this experimental system to gain some insights into the emergence of the spinal cord (http://dev.biologists.org/content/141/22/4243.full).
You can see a movie and some thoughts on the experiments here: http://www.cam.ac.uk/research/news/shaping-up-researchers-reconstruct-early-stages-of-embryo-development
More on this will follow soon.