New publication on “symmetry breaking in ensembles of ES cells”
Progress on our attempts to understand the connection between genes, signals, cells and embryos have just been published in Development. In a first paper we describe a new experimental system in which we coax mouse Embryonic Stem cells to make structures with an anterior posterior axis and a germ layer organization that resembles that of an embryo (http://dev.biologists.org/content/141/22/4231.full). In a second paper we use this experimental system to gain some insights into the emergence of the spinal cord (http://dev.biologists.org/content/141/22/4243.full).
You can see a movie and some thoughts on the experiments here: http://www.cam.ac.uk/research/news/shaping-up-researchers-reconstruct-early-stages-of-embryo-development
More on this will follow soon.
There are now videos of both the lecture and the subsequent panel discussion available at www.responsibleresearch.graduatecenter.uni-muenchen.de/presentations/videos/index.php
These are notes for a lecture given by AMA in a workshop about Responsible Research held at LMU in Munich (Germany) on 24 July 2014 (www.responsibleresearch.graduatecenter.uni-muenchen.de/index.html). The lecture is broken into two parts, the first one dealt with biomedical publishing, … Continue reading
We are interested in the structure and function of Living Matter with a special focus on the processes that generate tissues and organs from single cells through interactions between protein and gene regulatory networks. Cells use these networks to create and read programmes of gene expression and use these to interact with each other and differentiate into the multiple cell types that configure the building blocks of an organism. Our research is focused on how the activity of molecular networks is transformed into tissues for organ building. We address this problem through a combination of classical genetics, quantitative cell biology, image analysis and modelling.
We use mouse Embryonic Stem (ES) cells and Drosophila Intestinal Stem Cells (ISC) to ask questions about:
The lab has strong collaborations with Nicole Gorfinkiel (Centro Biologia Molecular, Madrid, Spain), Anne Grapin-Botton (Danish stem cell center: http://danstem.ku.dk/research1/grapin_laboratory/), Ana Katerina Hadjantonakis (Sloan Kettering Institute, New York, USA), Kathryn Lilley (Department of Biochemistry), Jenny Nichols (Cambridge Centre for Stem Cell Research), and Emma Rawlins (Gurdon Institute).
We also have strong collaborations with physicists and engineers which respond to the increasing need to trascend the data that is generated by classical biological approaches. In particular we have close interactions with Jordi Garcia Ojalvo (Universidad Pompeu Fabra: http://dsb.upf.edu/) and Jeremy Gunawardena (Department of Systems Biology)