If you are a biologist living in the world of the 90s, and there are many who do, you still have an urge to send your latest piece of work to one of those ‘glamour’ journals, as they are called … Continue reading
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New Publication: “Quantifying ES cells: A ß-catenin driven protein interaction network that buffers Oct4 to maintain pluripotency”
Muñoz-Descalzo, S., Rue, P., Faunes, F., Hayward, P., Jakt, L.M., Balayo, C., Garcia Ojalvo, J. and Martinez Arias, A. (2013) A competitive protein interaction network buffers Oct4-mediated differentiation to promote pluripotency in embryonic stem cells. Mol. Sys. Biol. 9 Article … Continue reading
We are interested in the structure and function of Living Matter with a special focus on the processes that generate tissues and organs from single cells through interactions between protein and gene regulatory networks. Cells use these networks to create and read programmes of gene expression and use these to interact with each other and differentiate into the multiple cell types that configure the building blocks of an organism. Our research is focused on how the activity of molecular networks is transformed into tissues for organ building. We address this problem through a combination of classical genetics, quantitative cell biology, image analysis and modelling.
We use mouse Embryonic Stem (ES) cells and Drosophila Intestinal Stem Cells (ISC) to ask questions about:
The lab has strong collaborations with Richard Adams and Guy Blanchard (Department of PDN ), Jenny Nichols (Cambridge Centre for Stem Cell Research), Kathryn Lilley (Department of Biochemistry), Nicole Gorfinkiel (Centro Biologia Molecular, Madrid, Spain), Ana Katerina Hadjantonakis (Sloan Kettering Institute, New York, USA), Jeremy Gunawardena (Department of Systems Biology, Harvard, USA), Barry Rosen (Sanger), and Emma Rawlins (Gurdon Institute).
We also have strong collaborations with physicists and engineers which respond to the increasing need to trascend the data that is generated by classical biological approaches. In particular we have close interactions with Ben Simons (The Cavendish Laboratory) and Jordi Garcia Ojalvo (Departament de Fisica I Enginyeria Nuclear Universitat Politecnica de Catalunya, Terrassa, Spain).